呂 思潔
專任老師
姓名 呂 思潔
電子郵件 cmbsycl@tmu.edu.tw
聯絡電話 02-27361661 #3916
研究專長
Immunomodulation of immune cells by mood stabilizers

愈來愈多研究證據顯示，在精神病患者之免疫狀況，其細胞調節性免疫反應和細胞激素之分泌皆有改變的情形，目前對於情緒穩定劑調節免疫細胞之研究並不多且意見分歧，因此，我們設定連續性計畫，來檢視其關係。
The effect of Chinese medicine in MMP activity on human fibroblast cell

研究中草藥物對於人類纖維細胞其基質金屬蛋白酶活性之影響，以篩選適合抗發炎反應之藥物。
開課
醫學科學研究所 分子免疫學特論
　
醫學科學研究所 專題討論(微免組)
　
醫學檢驗暨生物技術學系 普通生物學
職稱 教授
任別 專任
學歷 美國猶他州立大學 生物學研究所微免所 博士 1989 至 1992

美國猶他州立大學 生物學研究所微免所 碩士 1989

臺北醫學院 醫事技術學系 學士 1983 至 1986
服務機關名稱 單位 職務 期間
臺北醫學大學 醫學系微生物免疫學科 主任 2011.08 ~ 迄今
臺北醫學大學 醫學系微生物免疫學科 教 授 2011.01 ~ 迄今
臺北醫學大學 醫學系微生物免疫學科 副教授 2007.01 ~ 2011.12
臺北醫學大學 細胞及分子生物研究所 副教授 1994.01 ~ 2007.12
美國加州大學 聖地牙哥分校醫學部 博士後研究 1992.01 ~ 1994.12

近期重要著作

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年度 論文名稱
2019 1. Chang JB, Wu MF, Yang YY, Leu SJ, Chen YL, Yu CS, Chang SJ, Lu HF, Chung JG.Carbon tetrachoride-induced hepatotoxicity and its amelioration by agaricus blazei murrill extract in a mouse model In vivo 25:971-976.
2019 2. Charoenfuprasert S, Yang YY, Lee YC, Chao KC, Chu PY, Hsu KF, Chang KC, Chen YC , Chen LT, Chang JY, Leu SJ*, Shih NY*..Identification of salt inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer Oncogene 1:1-15.
2019 3. Lin RD, Mao YW, Leu SJ, Huang CY, Lee MH.The Immuno-Regulatory Effects of Schisandra chinensis and Its Constituents on Human Monocyte Leukemia Cells Molecules 16:4836-4849.
2019 4. Lin YF, Leu SJ, Huang HM, Tsai YH.Selective activation of specific PKC isoform dictating the fate of CD14+ monocytes towards differentiation or apoptosis. Journal of Cellular Physiology 226:122-131.
2019 5. Huang MC, Chen CH, Liu SC, Ho CC, Leu SJ*.Differential Patterns of Serum Brain-Derived Neurotrophic Factor Levels in Alcoholic Patients with and without Delirium Tremens. Alcoholism: Clinical and Experimental Research 35:126-131.
2019 6. Liu KJ, Lee YL, Yang YY, Shih NY, Ho CC, Wu YC, Huang TS, Huang MC, Liu HC, Shen WW, Leu SJ*.Modulation of the Development of Human Monocyte-Derived Dendritic Cells by Lithium Chloride Journal of Cellular Physiology 226:424-433.
2019 7. Huang MC, Ho CW, Chen CH, Liu SH, Chen CC, Leu SJ*.Reduced Expression of Circadian Clock Genes in Alcoholic Patients. Alcoholism: Clinical and Experimental Research 34:1899-1904.
2019 8. Leu SJ, Lee YC, Shih NY, Huang IJ, Liu KJ, Lu HF, Huang SY, and Yang YY *.Generation and Characterization of Anti-alpha-Enolase Single-Chain Antibodies in Chicken. Vet Immunol Immunopathol. 137:251-260.
2019 9. Lung J, Liu KJ, Chang JY, Leu SJ*, Shih NY*.MBP-1 is efficiently encoded by a novel transcriptional product of the ENO1 gene and stabilized by MG132 treatment FEBS Journal 277:4308-4321.
2019 10.Tai CJ, Lee YC, Lin EH, Wang HE, Luo TY, Fu YK, Chen HJ, Sun MD, Leu SJ*, Deng WP*, Wu CC, Kuo TH and Wu CH.Identification of a New Peptide for Fibrosarcoma Tumor Targeting and Imaging in Vivo Journal of Biomedicine and Biotechnology 167045:1-10.
2019 11.Tu SH, Chang CC, Chen CS, Tam KW, Wang YJ, Lee CH, Lin HW, Cheng TC, Huang CS, Chu JS, Shih NY, Chen LC, Leu SJ*, Ho YS*, Wu CH*.Increased expression of enolase alpha in human breast cancer confers tamoxifen resistance in human breast cancer cells Breast Cancer Res Treat 121:539-553.
2019 12. Liu KJ, Leu SJ, Su CH, Chiang BL, Chen YL, Lee YL.Administration of polysaccharides from Antrodia camphorata modulates dendritic cell function and alleviates allergen-induced Th2 responses in a mouse model of asthma. Immunology 129:351-362.
2019 13. Hsu CY, Liu HE, Sheu FY, Leu SJ, Chiang BL, Hsiao G, Lee YL.Synergistic therapeutic effects of combined adenovirus-mediated interleukin-10 and interleukin-12 gene therapy on airway inflammation in asthmatic mice. Journal of Gene Medicine 12:11-21.
2019 14. Chang CY, Lee YH, Leu SJ, Wang CY, Wei CP, Hung KS, Pai MH, Tsai MD, Wu CH..CCL18/PARC expression in the central nervous system with special reference to traumatic brain injuries and neoplastic disorders Neuroscience 165:1233-1243.
2019 15. Hsu CY, Leu SJ, Chiang BL, Liu HE, Su HC, Lee YL.Cytokine gene-modulated dendritic cells protect against allergic airway inflammation by inducing IL-10+IFN-γ+CD4+ T cells. Gene Therapy 17:1011-1021.
2019 16. Hu CJ, Lee YL, Shih NY, Yang YY, Charoenfuprasert S, Dai YS, Chang SM, Tsai YH, Tseng H, Liu CY, Leu SJ*.Reduction of monocyte chemoattractant protein-1 and interleukin 8 levels by ticlopidine in TNF-alpha stimulated human umbilical vein endothelial cells Journal of Biomedicine and Biotechnology 917837:1-6.
2019 17. Wu HH, Yang YY, Hsieh WS, Lee CH, Leu SJ, Chen MR.OmpA is the critical component for Escherichia coli invasion induced astrocyte activation J Neuropathol Exp Neurol 68:677-690.
2019 18. Lee YL, Lee MH, Chang HJ, Huang PY, Huang IJ, Chrng KT, Leu SJ.Taiwanese native plants inhibit matrix metalloproteinase-9 activity after ultraviolet B irradiation Molecules 14:1062-1071.
2019 19. Lee MH, Yang YY, Tsai YH, Lee YL, Huang PY, Huang IJ, Cheng KT, Leu SJ.The Effect of Chinese Herbal Medicines onTNF-a Induced Matrix Metalloproteinase -1, -9 Activities andInterleukin-8 Secretion Botanical Studies 49:301-309.
2019 20. Tsai MC, Wei CP, Lee DY, Tseng YT, Tsai MD, Shih YL, Lee YH Chang SF, Leu SJ.Inflammatory Mediators of Cerebrospinal Fluid from Patients with Spinal Cord Surgical Neurology 70:S1:19-24.
2019 21. Chen WC, Chiang BL, Liu HE, Leu SJ, Lee YL.Defective functions of circulating CD4+CD25+ and CD4+CD25_ T cells in patients with chronic ordinary urticaria J Dermatological Science 51:121-130.