吕 思洁
专任老师
姓名 吕 思洁
电子邮件 cmbsycl@tmu.edu.tw
联络电话 02-27361661 #3916
研究专长
Immunomodulation of immune cells by mood stabilizers

愈来愈多研究证据显示，在精神病患者之免疫状况，其细胞调节性免疫反应和细胞激素之分泌皆有改变的情形，目前对于情绪稳定剂调节免疫细胞之研究并不多且意见分歧，因此，我们设定连续性计画，来检视其关系。
The effect of Chinese medicine in MMP activity on human fibroblast cell

研究中草药物对于人类纤维细胞其基质金属蛋白酶活性之影响，以筛选适合抗发炎反应之药物。
开课
医学科学研究所 分子免疫学特论
　
医学科学研究所 专题讨论(微免组)
　
医学检验暨生物技术学系 普通生物学
职称 教授
任别 专任
学历 美国犹他州立大学 生物学研究所微免所 博士 1989 至 1992

美国犹他州立大学 生物学研究所微免所 硕士 1989

台北医学院 医事技术学系 学士 1983 至 1986
服务机关名称 单位 职务 期间
台北医学大学 医学系微生物免疫学科 主任 2011.08 ~ 迄今
台北医学大学 医学系微生物免疫学科 教 授 2011.01 ~ 迄今
台北医学大学 医学系微生物免疫学科 副教授 2007.01 ~ 2011.12
台北医学大学 细胞及分子生物研究所 副教授 1994.01 ~ 2007.12
美国加州大学 圣地牙哥分校医学部 博士后研究 1992.01 ~ 1994.12

近期重要着作

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年度 论文名称
2019 1. Chang JB, Wu MF, Yang YY, Leu SJ, Chen YL, Yu CS, Chang SJ, Lu HF, Chung JG.Carbon tetrachoride-induced hepatotoxicity and its amelioration by agaricus blazei murrill extract in a mouse model In vivo 25:971-976.
2019 2. Charoenfuprasert S, Yang YY, Lee YC, Chao KC, Chu PY, Hsu KF, Chang KC, Chen YC , Chen LT, Chang JY, Leu SJ*, Shih NY*..Identification of salt inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer Oncogene 1:1-15.
2019 3. Lin RD, Mao YW, Leu SJ, Huang CY, Lee MH.The Immuno-Regulatory Effects of Schisandra chinensis and Its Constituents on Human Monocyte Leukemia Cells Molecules 16:4836-4849.
2019 4. Lin YF, Leu SJ, Huang HM, Tsai YH.Selective activation of specific PKC isoform dictating the fate of CD14+ monocytes towards differentiation or apoptosis. Journal of Cellular Physiology 226:122-131.
2019 5. Huang MC, Chen CH, Liu SC, Ho CC, Leu SJ*.Differential Patterns of Serum Brain-Derived Neurotrophic Factor Levels in Alcoholic Patients with and without Delirium Tremens. Alcoholism: Clinical and Experimental Research 35:126-131.
2019 6. Liu KJ, Lee YL, Yang YY, Shih NY, Ho CC, Wu YC, Huang TS, Huang MC, Liu HC, Shen WW, Leu SJ*.Modulation of the Development of Human Monocyte-Derived Dendritic Cells by Lithium Chloride Journal of Cellular Physiology 226:424-433.
2019 7. Huang MC, Ho CW, Chen CH, Liu SH, Chen CC, Leu SJ*.Reduced Expression of Circadian Clock Genes in Alcoholic Patients. Alcoholism: Clinical and Experimental Research 34:1899-1904.
2019 8. Leu SJ, Lee YC, Shih NY, Huang IJ, Liu KJ, Lu HF, Huang SY, and Yang YY *.Generation and Characterization of Anti-alpha-Enolase Single-Chain Antibodies in Chicken. Vet Immunol Immunopathol. 137:251-260.
2019 9. Lung J, Liu KJ, Chang JY, Leu SJ*, Shih NY*.MBP-1 is efficiently encoded by a novel transcriptional product of the ENO1 gene and stabilized by MG132 treatment FEBS Journal 277:4308-4321.
2019 10.Tai CJ, Lee YC, Lin EH, Wang HE, Luo TY, Fu YK, Chen HJ, Sun MD, Leu SJ*, Deng WP*, Wu CC, Kuo TH and Wu CH.Identification of a New Peptide for Fibrosarcoma Tumor Targeting and Imaging in Vivo Journal of Biomedicine and Biotechnology 167045:1-10.
2019 11.Tu SH, Chang CC, Chen CS, Tam KW, Wang YJ, Lee CH, Lin HW, Cheng TC, Huang CS, Chu JS, Shih NY, Chen LC, Leu SJ*, Ho YS*, Wu CH*.Increased expression of enolase alpha in human breast cancer confers tamoxifen resistance in human breast cancer cells Breast Cancer Res Treat 121:539-553.
2019 12. Liu KJ, Leu SJ, Su CH, Chiang BL, Chen YL, Lee YL.Administration of polysaccharides from Antrodia camphorata modulates dendritic cell function and alleviates allergen-induced Th2 responses in a mouse model of asthma. Immunology 129:351-362.
2019 13. Hsu CY, Liu HE, Sheu FY, Leu SJ, Chiang BL, Hsiao G, Lee YL.Synergistic therapeutic effects of combined adenovirus-mediated interleukin-10 and interleukin-12 gene therapy on airway inflammation in asthmatic mice. Journal of Gene Medicine 12:11-21.
2019 14. Chang CY, Lee YH, Leu SJ, Wang CY, Wei CP, Hung KS, Pai MH, Tsai MD, Wu CH..CCL18/PARC expression in the central nervous system with special reference to traumatic brain injuries and neoplastic disorders Neuroscience 165:1233-1243.
2019 15. Hsu CY, Leu SJ, Chiang BL, Liu HE, Su HC, Lee YL.Cytokine gene-modulated dendritic cells protect against allergic airway inflammation by inducing IL-10+IFN-γ+CD4+ T cells. Gene Therapy 17:1011-1021.
2019 16. Hu CJ, Lee YL, Shih NY, Yang YY, Charoenfuprasert S, Dai YS, Chang SM, Tsai YH, Tseng H, Liu CY, Leu SJ*.Reduction of monocyte chemoattractant protein-1 and interleukin 8 levels by ticlopidine in TNF-alpha stimulated human umbilical vein endothelial cells Journal of Biomedicine and Biotechnology 917837:1-6.
2019 17. Wu HH, Yang YY, Hsieh WS, Lee CH, Leu SJ, Chen MR.OmpA is the critical component for Escherichia coli invasion induced astrocyte activation J Neuropathol Exp Neurol 68:677-690.
2019 18. Lee YL, Lee MH, Chang HJ, Huang PY, Huang IJ, Chrng KT, Leu SJ.Taiwanese native plants inhibit matrix metalloproteinase-9 activity after ultraviolet B irradiation Molecules 14:1062-1071.
2019 19. Lee MH, Yang YY, Tsai YH, Lee YL, Huang PY, Huang IJ, Cheng KT, Leu SJ.The Effect of Chinese Herbal Medicines onTNF-a Induced Matrix Metalloproteinase -1, -9 Activities andInterleukin-8 Secretion Botanical Studies 49:301-309.
2019 20. Tsai MC, Wei CP, Lee DY, Tseng YT, Tsai MD, Shih YL, Lee YH Chang SF, Leu SJ.Inflammatory Mediators of Cerebrospinal Fluid from Patients with Spinal Cord Surgical Neurology 70:S1:19-24.
2019 21. Chen WC, Chiang BL, Liu HE, Leu SJ, Lee YL.Defective functions of circulating CD4+CD25+ and CD4+CD25_ T cells in patients with chronic ordinary urticaria J Dermatological Science 51:121-130.