年度	论文名称
2010	1. Hsu CY, Leu SJ, Chiang BL, Liu HE, Su HC, Lee YL. (2010) Cytokine gene-modulated dendritic cells protect against allergic airway inflammation by inducing IL-10+IFN-γ+CD4+ T cells. Gene Therapy (in press) (SCI).
2010	2.Hu CJ, Lee YL, Shih NY, Yang YY, Charoenfuprasert S, Dai YS, Chang SM, Tsai YH, Tseng H, Liu CY, Leu SJ. (2010) Inhibition of monocyte chemoattractant protein-1 and interleukin-8 expression by ticlopidine in TNF-α stimulated human umbilical vein endothelial cells. Journal of Biomedicine and Biotechnology (in press) (SCI)
2010	3.Lee CC, Lin CP, Lee YL, Wang GC, Cheng YC, Liu HE. (2010) Meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. Leuk Lymphoma 51: 897-905 (SCI)
2010	4.Liu KJ, Leu SJ, Su CH, Chiang BL, Chen YL, Lee YL. (2010) Administration of polysaccharides from Antrodia camphorata extracts modulates the function of dendritic cells and tolerizes allergen-induced Th2 responses in a mouse model of asthma. Immunology (129):351-362 (SCI).
2010	5.Hsu CY, Liu HE, Sheu FY, Leu SJ, Chiang BL, Hsiao G, Lee YL. (2010) Synergistic therapeutic effects of combined adenovirus-mediated interleukin-10 and interleukin-12 gene therapy on airway inflammation in asthmatic mice. Journal of Gene Medicine (12):11-21 (SCI).
2010	6.Kuo YP, Lee YL, Tseng YH, Su CH, Burnouf T, Su CY. (2010) Influence of ethanol on the release of growth factors in human blood-derived platelet gels. Biologicals (38):120-127 (SCI).
2010	7.Li MH, Ooi HK, Lee YL, Liao CW, Lu SC, Huang HI, Su KE, Fan CK. (2010) Infectivity and development of Metagonimus yokogawai in domestic duck (Cairina moschata) experimentally infected with metacercaria.Vet Parasitology (168):45-50 (SCI)
2010	8.Leu JD, Lin CP, Lee YL, Liu HE. (2010) The activity of histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA) against human myeloid leukemia is associated with downregulation of c-Myc. Leukemia and Lymphoma (revised) (SCI)
2010	9.Lee YL, Liu KJ, Yang YY, Shih NY, Ho CC,Wu YC, Huang TS, Huang MC, Liu HC, Shen WW, Leu SJ. (2010) Lithium chloride modulates the differentiation and function of human monocyte-derived dendritic cells through multiple pathways. Journal of Immunology (submit) (SCI)
2009	12.Lee YL, Lee MH, Chang HJ, Huang PY, Huang IJ, Cheng KT, Leu SJ. (2009) Taiwanese Native Plants Inhibit Matrix Metalloproteinase-9. Molecules (14):1062-1071(SCI).
2009	13.Liao CW, Lee YL, Sukati H, D’lamini P, Huang, YC, Chiu, CJ, Liu, YH, Chou CM, Du WY, Hung CC, Chan HC, Chu B, Tu CC, Fan CK. (2009) Seroprevalence of Toxoplasma gondii infection among children in Swaziland, southern Africa. Annals of Tropical Medicine Parasitology (103):731-736 (SCI).
2008	14.Chen WC, Chiang BL, Liu HE, Leu SJ, Lee YL*. (2008) Defective functions of circulating CD4+CD25+ and CD4+CD25- T cells in patients with chronic ordinary urticaria. Journal of Dermatological Science (51):121-130 (SCI).
2008	15.Lee MH, Yang YY, Tsai YH, Lee YL, Huang PY, Huang IJ, Cheng KT, Leu SJ. (2008) The effect of Chinese herbal medicines on TNF-α induced matrix metalloproteinase-1, -9 activities and interleukin-8 secretion. Botanical Studies (49):301-309 (国科会优良期刊)
2006	16.Fu CL, Ye YL, Lee YL, Chiang BL. (2006) Effects of overexpression of IL-10, IL-12, TGF-beta and IL-4 on allergen induced change in bronchial responsiveness. Respiratory Research (7):72-85 (SCI).
2004	17.Ye, Y.-L., Lee Y.-L., Chuang, Z.-J., Lai, H.-J., Chen, C,-C., Taio, M,-H., and Chiang, B,-L. (2004) Cytokine expressing adenovirus modulated dendritic cells alleviate eosinophilia and airway hyperresponsiveness in an animal model of asthma. Journal of Allergy and Clinical Immunology; 114:88-96.(SCI)
2003	18.Chiang, D.-J., Ye, Y.-L., Chen, W.-L., Lee, Y.-L., Hsu, N.-Y., and Chiang, B.-L. (2003) Ribavirin or CpG DNA sequence modulated dendritic cells decrease IgE level and airway inflammation. American Journal of Respiratory and Critical Care Medicine; 168: 575-580.(SCI)
2003	19.Fu, C.-L., Ye, Y.-L., Lee Y.-L., and Chiang, B.-L. (2003) Both type 2 allergen-specific CD4 and CD8 T lymphocytes are decreased in asthmatic children receiving immunotherapy. Pediatric Allergy and Immunology; 14: 284-291.(SCI)
2002	20.Ye, Y.-L., Huang, W.-C., Lee, Y.-L., and Chiang, B.-L. (2002) IL-12 inhibits eotaxin secretion of cultured primary lung cells and alleviates airway inflammation in vivo. Cytokine; 19:76-84
2001	21.Lee, Y.-L., Ye, Y.-L., Yu, C.-I., Wu, Y.-L., Lai, Y.-L., Kuo, P.-H., Hong, R.-L., and Chiang, B.-L. (2001) Construction of single-chain interleukin-12 DNA plasmid to treat airway hyperresponsivenss in an animal model of asthma. Human Gene Therapy; 12:2065-2079.(SCI)
2000	10.专利申请: 外膜蛋白A于治疗/预防/诊断由克雷白氏肺炎杆菌(KLEBSIELLA PNEUMONIAE)及其他革兰氏阴性菌引起的感染之用途. (中华民国第098103085号专利申请案, 杨沂渊、吴雪霞、吕思洁、施能耀、黄怡仁、林景堉、谢文祥、刘柯俊、黄士懿、李岳伦、李吉昕、何元顺、徐士兰等) (2009年01月23日向台湾专利暨商标局送件申请).
2000	11.USE OF OUTER MEMBRANE PROTEIN A (OMPA) IN TREATMENT/PREVENTION/DIAGNOSIS OF INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE AND OTHER GRAM-NEGATIVE BACTERIA. (美国第12/359,205号实用专利部分接续申请案(CIP), Yang YY, Wu HH, Leu SJ, Shih NY, Huang IJ, Liu, CY, Hsieh WS, Liu KJ, Huang SY, Lee YL, Lee CH, Ho, YS, Hsu, SL) (已通过).
1999	22.Lee, Y.-L., Fu, C.-L., and Chiang, B.-L. (1999) Administration of interleukin-12 exerts a therapeutic instead of a long-term preventive effect on mite Der p 1 allergen-induced animal model of airway inflammation. Immunology 97:232-240.(SCI)
1999	项目符号 TEL : 02-27361661 #3912 项目符号 FAX : 02-27361661 #3121 项目符号 E-Mail : yllee@tmu.edu.tw 　 　 　 　 　 项目符号 国立台湾大学 微免所 博士 1993 至1998 项目符号 国立台湾大学 微免所 硕士 1990 至1992 项目符号 国立阳明大学 医技系 学士 1986 至1990 　 　 　 　 　 项目符号 台北医学大学 医学系微生物免疫学科 副教授 2010 – 迄今 项目符号 台北医学大学 医学系微生物免疫学科 助理教授 2003 / 08 ~2009 项目符号 国立台湾大学 临床医学研究所 博士后研究 1998/ 10 至2003/07 项目符号 国立台湾大学 微免科 助教 1992 / 08至1993/07 　 　 　 　 　 项目符号 过敏气喘，细胞免疫，基因治疗、保健食品开发: 从1970年代以来，许多报告都指出，全世界气喘病的罹患率持续在增加，病情转趋严重，住院率和死亡率也随着增高，台湾地区也不例外。在气喘病人身上可观察到几项特征：包括血液中的IgE增加，体内第二型T辅助细胞(Th2)数目增加，气管聚集大量的嗜伊红性白血球细胞(eosinophilia)以及发炎媒介物的产生。过去对气喘疾病的治疗大部分偏重于抑制气管的发炎现象和舒缓气管的收缩程度，而吸入性类固醇的使用为目前对于气喘症状控制和肺功能的改善最有效的方法；但是类固醇的使用只能抑制发炎现象，对气喘仍无法根治，而且对于人体仍有潜在的副作用，所以病人除了尽量避免接触过敏原外，要彻底治疗气喘疾病，目前治疗方法为减敏疗法。减敏治疗必须持续几年的治疗，此种耗时并且需要大量纯化过敏原的治疗方式并不是最理想的治疗方法。基于此，其病因的探讨和研发过敏气喘新治疗的方法则刻不容缓。 在大家致力研发气喘疾病的治疗新方法中，有两种策略是被认为最具有发展潜力的： (1) 发展出能诱发气喘病人体内第一型T辅助细胞(Th1)免疫反应的疫苗，用来抑制过敏性第二型T辅助细胞(Th2)的免疫作用。而目前已知细胞激素IL-12, IL-18, IL-27以及IFN-g皆可用于引发Th1细胞的免疫反应。 (2) 发展出能诱发气喘病人体内调节性T细胞(Treg)免疫反应的疫苗，用来抑制过敏性第二型T辅助细胞(Th2)的免疫反应。而目前则认为细胞激素IL-10可做为佐剂，用来帮助病人体内调节性T细胞的生成，进而抑制Th2细胞的免疫作用。 敝研究室主要研究方向是探讨过敏疾病的治病机转，并利用此依研究结果来研发近一步的免疫疗法。多年前我们研究室就已经开始将IL-12、IL-10、益生菌及樟芝保健食品的纯化物应用到过敏气喘动物的治疗与预防，在对于预防或减缓气管发炎的小鼠上皆获得不错的成绩。目前，则致力于开发更有效的治疗产品与治疗方式，我们的实验室将使用各种(1)表现Notch配位子基因的载体；(2)类铎受器(Toll-like receptor)促效剂；(3)益生菌；(4) 西洋蔘达玛烷苷；(5)纳豆发酵纯化物…等；评估这些物质在气管发炎的动物模式下，是否能建立一个更有效的治疗的新方法。 　 　 　 　 　 　 　 项目符号 期刊论文 1. Hsu CY, Leu SJ, Chiang BL, Liu HE, Su HC, Lee YL. (2010) Cytokine gene-modulated dendritic cells protect against allergic airway inflammation by inducing IL-10+IFN-γ+CD4+ T cells. Gene Therapy (in press) (SCI). 2.Hu CJ, Lee YL, Shih NY, Yang YY, Charoenfuprasert S, Dai YS, Chang SM, Tsai YH, Tseng H, Liu CY, Leu SJ. (2010) Inhibition of monocyte chemoattractant protein-1 and interleukin-8 expression by ticlopidine in TNF-α stimulated human umbilical vein endothelial cells. Journal of Biomedicine and Biotechnology (in press) (SCI) 3.Lee CC, Lin CP, Lee YL, Wang GC, Cheng YC, Liu HE. (2010) Meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. Leuk Lymphoma 51: 897-905 (SCI) 4.Liu KJ, Leu SJ, Su CH, Chiang BL, Chen YL, Lee YL. (2010) Administration of polysaccharides from Antrodia camphorata extracts modulates the function of dendritic cells and tolerizes allergen-induced Th2 responses in a mouse model of asthma. Immunology (129):351-362 (SCI). 5.Hsu CY, Liu HE, Sheu FY, Leu SJ, Chiang BL, Hsiao G, Lee YL. (2010) Synergistic therapeutic effects of combined adenovirus-mediated interleukin-10 and interleukin-12 gene therapy on airway inflammation in asthmatic mice. Journal of Gene Medicine (12):11-21 (SCI). 6.Kuo YP, Lee YL, Tseng YH, Su CH, Burnouf T, Su CY. (2010) Influence of ethanol on the release of growth factors in human blood-derived platelet gels. Biologicals (38):120-127 (SCI). 7.Li MH, Ooi HK, Lee YL, Liao CW, Lu SC, Huang HI, Su KE, Fan CK. (2010) Infectivity and development of Metagonimus yokogawai in domestic duck (Cairina moschata) experimentally infected with metacercaria.Vet Parasitology (168):45-50 (SCI) 8.Leu JD, Lin CP, Lee YL, Liu HE. (2010) The activity of histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA) against human myeloid leukemia is associated with downregulation of c-Myc. Leukemia and Lymphoma (revised) (SCI) 9.Lee YL, Liu KJ, Yang YY, Shih NY, Ho CC,Wu YC, Huang TS, Huang MC, Liu HC, Shen WW, Leu SJ. (2010) Lithium chloride modulates the differentiation and function of human monocyte-derived dendritic cells through multiple pathways. Journal of Immunology (submit) (SCI) 10.专利申请: 外膜蛋白A于治疗/预防/诊断由克雷白氏肺炎杆菌(KLEBSIELLA PNEUMONIAE)及其他革兰氏阴性菌引起的感染之用途. (中华民国第098103085号专利申请案, 杨沂渊、吴雪霞、吕思洁、施能耀、黄怡仁、林景堉、谢文祥、刘柯俊、黄士懿、李岳伦、李吉昕、何元顺、徐士兰等) (2009年01月23日向台湾专利暨商标局送件申请). 11.USE OF OUTER MEMBRANE PROTEIN A (OMPA) IN TREATMENT/PREVENTION/DIAGNOSIS OF INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE AND OTHER GRAM-NEGATIVE BACTERIA. (美国第12/359,205号实用专利部分接续申请案(CIP), Yang YY, Wu HH, Leu SJ, Shih NY, Huang IJ, Liu, CY, Hsieh WS, Liu KJ, Huang SY, Lee YL, Lee CH, Ho, YS, Hsu, SL) (已通过). 12.Lee YL, Lee MH, Chang HJ, Huang PY, Huang IJ, Cheng KT, Leu SJ. (2009) Taiwanese Native Plants Inhibit Matrix Metalloproteinase-9. Molecules (14):1062-1071(SCI). 13.Liao CW, Lee YL, Sukati H, D’lamini P, Huang, YC, Chiu, CJ, Liu, YH, Chou CM, Du WY, Hung CC, Chan HC, Chu B, Tu CC, Fan CK. (2009) Seroprevalence of Toxoplasma gondii infection among children in Swaziland, southern Africa. Annals of Tropical Medicine Parasitology (103):731-736 (SCI). 14.Chen WC, Chiang BL, Liu HE, Leu SJ, Lee YL*. (2008) Defective functions of circulating CD4+CD25+ and CD4+CD25- T cells in patients with chronic ordinary urticaria. Journal of Dermatological Science (51):121-130 (SCI). 15.Lee MH, Yang YY, Tsai YH, Lee YL, Huang PY, Huang IJ, Cheng KT, Leu SJ. (2008) The effect of Chinese herbal medicines on TNF-α induced matrix metalloproteinase-1, -9 activities and interleukin-8 secretion. Botanical Studies (49):301-309 (国科会优良期刊) 16.Fu CL, Ye YL, Lee YL, Chiang BL. (2006) Effects of overexpression of IL-10, IL-12, TGF-beta and IL-4 on allergen induced change in bronchial responsiveness. Respiratory Research (7):72-85 (SCI). 17.Ye, Y.-L., Lee Y.-L., Chuang, Z.-J., Lai, H.-J., Chen, C,-C., Taio, M,-H., and Chiang, B,-L. (2004) Cytokine expressing adenovirus modulated dendritic cells alleviate eosinophilia and airway hyperresponsiveness in an animal model of asthma. Journal of Allergy and Clinical Immunology; 114:88-96.(SCI) 18.Chiang, D.-J., Ye, Y.-L., Chen, W.-L., Lee, Y.-L., Hsu, N.-Y., and Chiang, B.-L. (2003) Ribavirin or CpG DNA sequence modulated dendritic cells decrease IgE level and airway inflammation. American Journal of Respiratory and Critical Care Medicine; 168: 575-580.(SCI) 19.Fu, C.-L., Ye, Y.-L., Lee Y.-L., and Chiang, B.-L. (2003) Both type 2 allergen-specific CD4 and CD8 T lymphocytes are decreased in asthmatic children receiving immunotherapy. Pediatric Allergy and Immunology; 14: 284-291.(SCI) 20.Ye, Y.-L., Huang, W.-C., Lee, Y.-L., and Chiang, B.-L. (2002) IL-12 inhibits eotaxin secretion of cultured primary lung cells and alleviates airway inflammation in vivo. Cytokine; 19:76-84 21.Lee, Y.-L., Ye, Y.-L., Yu, C.-I., Wu, Y.-L., Lai, Y.-L., Kuo, P.-H., Hong, R.-L., and Chiang, B.-L. (2001) Construction of single-chain interleukin-12 DNA plasmid to treat airway hyperresponsivenss in an animal model of asthma. Human Gene Therapy; 12:2065-2079.(SCI) 22.Lee, Y.-L., Fu, C.-L., and Chiang, B.-L. (1999) Administration of interleukin-12 exerts a therapeutic instead of a long-term preventive effect on mite Der p 1 allergen-induced animal model of airway inflammation. Immunology 97:232-240.(SCI)
1999	23.Lee, Y.-L., Fu, C.-L., Ye, Y.-L., and Chiang, B.-L. (1999) Administration of IL-12 prevents mite Der p 1allergen-IgE antibody production and airway eosinophil infiltration in an animal model of airway inflammation. Scand. J. Immunol. 49:229-236.(SCI)
1998	24.Chow, Y.-H., Chiang, B.-L., Lee, Y.-L., Chi, W.-K., Lin, W.-C., Chen, Chen, Y.-T., and Tao, M.-H. (1998) Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes. Journal of Immunology 160:1320-1329. (SCI)
1998	25.Lee, Y.-L., Tao, M.-H., Chow, Y.-H., and Chiang, B.-L. (1998) Construction of vectors expressing bioactive heterodimeric and single-chain murine interleukin-12 for gene therapy. Human Gene Therapy 9:457-465.(SCI)